Probucol prevents oxidative injury to endothelial cells.

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Probucol prevents oxidative injury to endothelial cells.

We evaluated the effect of the antioxidant, probucol, on the cytotoxic effects of oxidized low density lipoprotein (OX-LDL) or of cumene hydroperoxide (CumOOH) on cultured bovine endothelial cells (EC). The addition of CumOOH to EC caused the release of lactate dehydrogenase and the accumulation of thiobarbituric acid-reacting substances (TBARS), effects that were protected against by preincuba...

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ژورنال

عنوان ژورنال: Journal of Lipid Research

سال: 1991

ISSN: 0022-2275

DOI: 10.1016/s0022-2275(20)42080-2